Journal article
Body size and risk for colorectal cancers showing BRAF mutations or microsatellite instability: A pooled analysis
LAE Hughes, EJ Williamson, M Van Engeland, MA Jenkins, GG Giles, JL Hopper, MC Southey, JP Young, DD Buchanan, MD Walsh, PA Van den Brandt, R Alexandra Goldbohm, MP Weijenberg, DR English
International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2012
DOI: 10.1093/ije/dys055
Abstract
Background How body size influences risk of molecular subtypes of colorectal cancer (CRC) is unclear. We investigated whether measures of anthropometry differentially influence risk of tumours according to BRAF c.1799T>A p.V600E mutation (BRAF) and microsatellite instability (MSI) status. Methods Data from The Netherlands Cohort Study (n = 120 852) and Melbourne Collaborative Cohort Study (n = 40 514) were pooled and included 734 and 717 colorectal cancer cases from each study, respectively. Hazard ratios (HRs) and 95% confidence intervals (CIs) for body mass index (BMI), waist measurement and height were calculated and compared for subtypes defined by BRAF mutation and MSI status, measured ..
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Grants
Awarded by European Association for Cancer Research
Funding Acknowledgements
World Cancer Research Fund (WCRF) (Grant No. 2007/54 to M. P. W.); European Association for Cancer Research (travel fellowship to L. A. E. H.); Dutch Cancer Society (KWF) (travel fellowship to L.A.E.H.).